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Congenital self-healing Langerhans cell histiocytosis in a male neonate Tan Q, Gan LQ, Wang H

Dandy-Walker syndrome (DWS) is a rare brain malformation involving the cerebellum, and the fluid filled spaces around it, usually detected during the antenatal period or the early infancy. We report a neonate who presented with hypothermia and severe hypoglycemia. Associated CNS abnormalities included metabolic encephalopathy, hemorrhage and cerebral hypoxia. Skin lesion morphologic traits did not correlate with extent of extracutaneous disease. PUV and its consequences, including renal dysplasia, upper tract dilatation, vesico-ureteric reflux, urinary tract infection and bladder dysfunction, accounts for 25 – 30 % of pediatric renal transplantations in the UK (UK Transplant Registry). Pituitary hormone deficiencies can evolve, so regular monitoring, both clinically and with investigations, is needed. They are roughly 20-30ml/kg/day in a neonate or 400ml/m2/day in an older child.


coli (16.7%). Additionally, the examination of the anterior fontanel in infants is of paramount importance. Concurrent neurological comorbidity at diagnosis (odds ratio = 2.8, P = .029) predicted poor outcome. Tzanck smear was negative for multinucleated giant cells. Furosemide may cause electrolyte and acid-base disturbances, including hyponatremia, hypochloremia, hypokalemia, and metabolic alkalosis. Hypoglycaemia was corrected with dextrose infusion. Better strategies aimed at early detection and reducing the emergence of neurologic complications and aggressive treatment of Group B streptococcus sepsis are needed in neonates with meningitis and septic shock.

The initial serum sodium was 185 mEq/L and potassium was 4.8 mEq/L. Immunohistochemistry examination showed that most of the histiocytes were positive for S-100 protein [Figure 3], CD1a [Figure 4], and CD68. Electron microscopic examination demonstrated Birbeck (Langerhans) granules within the cytoplasm of some of the histiocytes. Treatment Infected cyst treated with antibiotic to cover oropharyngeal flora (aerobes and anaerobes) and warm compresses. European Milk Banking Association Meeting. Anal fissures are painful and may result in streaks of bright red blood on the outside of the stool or on toilet paper. Imbalances in sex hormone may result in a delay in sexual development (puberty) or precocious puberty.

Hagadorn, Anne M. After cAMP is generated by adenylate cyclase, it is degraded by phosphodiesterase. The skin lesions of Langerhans cell histiocytosis exhibit a wide spectrum of morphology. The most common initial skin lesion is erythematous, often crusted, and contains vesiculo-pustules. [2] It is important to distinguish this condition from other vesiculo-bullous diseases present in neonates, including disseminated herpes simplex, varicella, cytomegalovirus, congenital candidiasis, impetigo neonatorum, congenital syphilis, erythema toxicum neonatorum, transient neonatal pustular melanosis, epidermolysis bullosa, and incontinentia pigmenti. While the serum growth hormone (7.8 ng/ml) and insulin (2 mU/L) levels were within the normal range, the cortisol (0,74 g/dL) was lower than normal, compatible with adrenal insufficiency. In our case, the neonate was well and had no evidence of bacterial, fungal, and viral infections.

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