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? – Changing from Levemir to Prozinc ???? | Feline Diabetes Message Board


Princeton, NJ (June 27, 2006) – Novo Nordisk announced today a victory in a lawsuit in which Sanofi-Aventis sought a preliminary injunction against Novo Nordisk’s pre-launch and launch materials for Levemir® (insulin detemir [rDNA origin] injection), Novo Nordisk’s new long-acting basal insulin. It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Levemir. Levemir has now become part of the treatment program for dogs who metabolize the usual Intermediate-acting insulins too quickly, thus having less duration than would normally be expected from them. But what exactly does that mean? Two large randomized controlled trials (4,5) of women with gestational diabetes mellitus, variously diagnosed, have demonstrated that treating and reducing glucose levels during pregnancy reduces many of these complications. acknowledge that the benefits of insulin glargine and insulin detemir compared to those of neutral protamine Hagedorn (NPH) insulin had been established at the time the L2T3 study was designed.2–4 However, the authors questioned the efficacy of detemir in a once-daily regimen based on the results of one regulatory submission study5 and one other study, by Hermansen et al.,2 that evaluated detemir and NPH in twice-daily dosing regimens. Total hypoglycaemic episodes in the 4 weeks prior to study start were 47.5 per patient-year in patients with type 1 and 9.2 per patient-year in patients with type 2 diabetes.

Penfill cartridges come in packages of five, with each cartridge containing 3mL of insulin detemir (a total of 1500 units per package). The daily doses of insulin detemir and aspart in group 1 were adjusted by telephone weekly based on blood glucose monitoring until stabilization occurred. Because glargine is not soluble at a neutral pH, it precipitates out into a form that’s not soluble in subcutaneous fat, and there forms a relatively insoluble depot. Levemir, manufactured by Novo Nordisk, begins working in the body 2-4 hours after injection, and doesn’t peak. Some people shoot an 11/13 cycle if the preshots are unequal. Mean prepregnancy weight was 85.9 kg (range 52.2–135.5 kg) and weight at delivery was 100.5 kg (range 65.9–129 kg). She reported a similar painful episode 4 weeks prior.

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