[ Diabetes Solutions ]

Calcitriol Improves Streptozotocin-induced Diabetes and Recovers Bone Mineral Density in Diabetic Rats


OBJECTIVE—Type 1 diabetes has been associated with decreased bone mineral density (BMD). Adolescents with type 1 diabetes mellitus may not reach potential peak bone mass, putting them at greater fracture risk. “Osteoporosis is well-described in adult women with long-standing diabetes, but there is not a lot of information on when it starts,” said Teresa Quattrin, M.D., UB associate professor of pediatrics and lead researcher on the study. References of relevant studies were also searched. Falahati moved the practice into his own medical building. Another chronic and highly prevalent condition is diabetes mellitus, which affects more than 380 million people; both type 1 and type 2 diabetes are risk factors for fracture. Also, there were no significant differences in body weight and blood glucose, as well as blood glycosylated hemoglobin (HbAIc%), serum Ca, alanine aminitransperase (ALT), aspartate aminotransferase (AST), uric acid (UA), nonesterified fatty acid (NEFA), cholinesterase (CHE), and creatinine (CR) levels between diabetic and Mg-implanted rats.

This increases your chances of falling, which is a major cause of further fractures. Finally, bone mineral density (BMD) of tibia and lumbar vertebrae were evaluated. The National Osteoporosis Foundation reports that this amount is $13.8 billion per year, and that is expected to double over the next 25 years. At the end of the experiment, DT animals were separated into two groups, those still remaining diabetic (DT-NR) and reversed animals (DT-R). Moreover, bone loss was observed in diabetic animals (D), whereas BMD of DT-R rats showed similar values to those of controls (C). Our results suggest that 1.25(OH)2D3 improves diabetes and, as such, may recover BMD in streptozotocin-induced diabetic rats.

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