[ Diabetes Type 2 ]

Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes

3.Soskic SS, Dobutovic BD, Sudar EM, Obradovic MM, Nikolic DM, Djordjevic JD, Radak DJ, Mikhailidis DP, Isenovic ER. The cause of this dysfunction has been unknown. Furthermore, hyperglycaemia evolves with time and even with rigorous treatment there is a progressive deterioration of glucose homeostasis. Quantitative trait analyses were performed in up to 5,744 Inter99 participants naïve to glucose-lowering medication. Troglitazone, for example, demonstrated improvements in insulin secretory capacity in isolated pancreatic islets from Wistar rats and a hamster beta-cell line. Vincent Poitout (Montreal, Canada) highlighted the importance of cell-membrane receptors coupled to the G protein (GPCRs), specifying that these represent potential targets of a number of therapeutic strategies. Never before has the importance of nicotine-sensitive receptors been shown in terms of the function of beta cells.

Rabinovitch spoke to Medscape recently about the project and the tremendous possibilities offered by this research. FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. n = 3. Despite this level of glycemic control, no difference was found in the incidence of hypoglycemia between the liraglutide and placebo groups (P = 0.61). M. taken from a living individual. Journal of Clinical Investigation (2008) 118(10):3378-3389.

Determination of the absolute magnitude of ΔψM that is required for the comparison of diseased and normal individuals has been previously unattainable due to fundamental biophysical processes interfering with the readout of otherwise commonly used fluorescence sensor molecules. At first, the adult beta cell was considered to be post-mitotic with little capacity for regeneration. This is a similar proportion of beta cells positive for MafA in insulin-expressing cells present in human pancreatic endoderm directed towards an endodermal lineage. We report a marked decrease in beta cells with nuclear MafA in pancreatic samples from individuals with type 2 diabetes. Loss of β-cell identity is a potential contributory factor toward β-cell dysfunction in diabetes, although the percentage of cells described in the current study (7) (∼4%) seems too small to induce diabetes.

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