RESEARCH DESIGN AND METHODS In this euglycemic glucose clamp study, 10 male subjects with type 1 diabetes received three different subcutaneous insulin infusion rates (0.5, 1.0, and 2.0 units/h; for 4 h each) of insulin lispro (IL) with insulin pumps. This study aimed to assess efficacy and safety of insulin degludec injected once a day or three times a week compared with insulin glargine once a day in insulin-naive people with type 2 diabetes, who were inadequately controlled with oral antidiabetic drugs. We summarized clinical data from randomized clinical trials designed to compare the efficacy and safety of basal-bolus and premixed insulin intensification regimens. −1.31%, P = 0.0003), and more patients reached HbA1c ≤7.0% without confirmed nocturnal hypoglycemia (45.5 vs. If you are unsure about whether your background insulin needs changing, a good way to check is do a fasting test, which involves not eating and not injecting short term insulin for several hours. We conclude that platelet hyperactivation was detectable in well-controlled diabetic patients without complications. Increasing age, duration of diabetes, oral antihyperglycaemic agent usage and Charlson comorbidity index score were associated with a significant delay in the time to intensification (p < 0.05). NPH). Patients were randomized according a 2:2:1 ratio to one of three regimens: a basal-bolus regimen with insulin glargine given once daily and glulisine before meals plus corrective doses of glulisine by sliding scale for BG >140 mg/dL (Lantus and Apidra; Sanofi), a basal plus regimen with a daily dose of glargine and corrective doses of glulisine by sliding scale before meals for BG >140 mg/dL, or SSI for BG >140 mg/dL (Novolin R; Novo Nordisk). 8%), vomiting (18% vs. This was a randomized, placebo-controlled, double-blind phase IIb study, conducted from November 2009 to May 2012 in 97 centres in seven countries (Denmark, France, Ireland, Korea, Portugal, UK and USA). It’s sort of equivalent to, I don’t know, say… the end of the world, for me. When Gary asked me not to eat until 1pm, I just about had a conniption fit.
I emailed to explain: I’m one of those people who MUST eat right away when I get up in the am … If you want to use the same rate for the whole day, press ESC and skip to step 10. Not good. Gary, I don’t think you fully understand. This has nothing to do with being ‘brave.’ I talked it over with my husband, and he’s not keen on me doing it — but if so, then we need to plan carefully for a day when he can fully take over feeding the family in the morning and I don’t need to go anywhere. It may take a little time before the ‘stars align’ for this. That went pretty well, since I distracted myself by planning it on a night when hubby and I were invited to a cocktail party.
I drank Diet Coke only, and steered far, far away from the food tables. I tested dutifully at 5pm, 7pm, 9pm, and 10pm. After that I was allowed to eat. Tuna salad never tasted so good. Next up, skipping lunch. I am not looking forward to this one, either, in which I’m not to eat or drink anything with calories between 8am and 4pm — with testing at noon, 2pm, and 4pm. I’m hoping for a day with a really good distraction.
baseline) (Fig. Whine, whine, whine, I know. I am well aware that most people living with chronic illnesses have bigger problems than being asked to skip a meal now and then. I just find it unusually unpleasant. And it’s the additive effect that gets to me: the constant testing and dosing and correcting, carrying all the backups, the midnight lows with the sweating and the unwanted eating, and the bouncing back up way too high — not to mention the fact that other people can eat and do as they like without all this crap (just ask Kris Freeman). Grrrrr. This content is created for Diabetes Mine, a consumer health blog focused on the diabetes community.
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