[ Diabetes Type 2 ]

Association between microalbuminuria and cardiovascular disease in type 2 diabetes mellitus of the Beijing Han

In persons with diabetes, chronic hyperglycemia (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated hemoglobin to macrovascular disease is less clear. Sheludiakova of University of Sydney in Sydney, Australia and colleagues found rats drinkingsugary beverages got more abdominal fat, higher levels of triglycerides, and developed impairedinsulin/glucose homeostasis, compared to those drinking water, even though the former did not gain more weight than the latter.The researchers gave Male Hooded Wister rats free access to a drink with 10 percent sucrose or a 10 percentfructose/glucose (50/50) drink or water as controls in addition to a normal diet for 56 days, which isequivalent to four years for humans. It would be clinically valuable to have a risk marker at the time of pregnancy so that long-term follow up and possible interventions can be focused on the women at greatest risk in a timely manner. The metabolic syndrome risk factor burden and fasting insulin were also shown to affect the risk of developing future T2DM. Results: Serum activin A and the activin A/follistatin ratio were increased in patients with T2DM and coronary artery disease (CAD) compared with healthy volunteers and the elevated activin A was associated with the severity of coronary atherosclerotic burden as determined by the proportion of ≥2 vessel disease (p = 0.035) after multivariable-adjusted trend analysis. The prevalence of IGF, IGT, screen-detected T2DM, MS, and CVD was higher in SO patients than in the other groups. Under-reporting of people with AIDS (PWA) has been estimated at about 5% [14], whereas the vital status of PWA is not routinely kept up-to-date.

These recommendations are also appropriate for secondary prevention. This study’s purpose was to assess CHD survivors’ risk for type 2 diabetes mellitus (T2DM) with attention to the impact of cyanotic CHD. In fact, a Finnish study found that people with type 2 diabetes who have no history of CHD have the same risk of a heart attack as those without diabetes who have already had a heart attack. The long-term efficacy of dapagliflozin to maintain reductions in HbA1c, SBP and body weight over 2 years, together with its tolerability profile, make dapagliflozin an appropriate option in high-risk patients with T2DM and CVD. It is concluded that major advances in our understanding of the prothrombotic state in DM have been made. Conclusion: Microalbuminuria in patients with T2DM is another risk factor for CHD. A possible explanation for this finding is selective drop-out (‘healthy survivors effect’) in the group osteoarthritis patients.

An UAER value of 11.275 μg/min can be used to predict the risk of CHD in patients with T2DM.

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