Despite extensive searches we identified only 18 published reports of paediatric trials including standardised QOL measures. The DQOL and NHP were administered to 150 adult patients with type 1 diabetes mellitus (DM1) and 146 adult patients with type 2 (DM2). A standard backward and forward translation procedure was used to convert the English version of the DQOL into the Iranian language (Persian). Health-related quality of life was measured with the generic questionnaire Short Form-36, consisting of eight dimensional scores. Known-groups validity was examined using laboratory indicators (fasting, 2-hour postprandial plasma glucose, and hemoglobin A1c), presence of diabetic complications (retinopathy, nephropathy, neuropathy, diabetic foot disorder, cardiovascular and cerebrovascular disorders), and psychosocial variables (sense of well-being and self-reported diabetes severity). Metformin, compared with insulin either alone or in combination had the most favourable overall impact on patient reported quality of life and treatment satisfaction. The two overview items (QA and QB) provide global measures of an individual’s present QoL, and the perceived impact of diabetes and its treatment on their QoL respectively and, as expected, QB has a higher correlation with AWI than QA, as both QB and AWI measure impact of diabetes on QoL.
The glycemic variability was significantly higher for MDI participants compared to CSII participants (P < .05 for all glycemic variability measures), but no significant difference in QoL between the 2 treatment modality groups was observed. If we value QoL as a therapeutic goal, we must ensure that the instruments we use are both valid and reliable. DQOLY-SF includes scales of future worries, parental concern, impact on activities, impact of treatment, symptom impact, and satisfaction. Only one parent or caregiver per child participated; the participant was required to be the primary caregiver of the child, and had to be willing to participate throughout the course of the study and to complete the questionnaires at Weeks 0 and 2. The programme used empowerment-based principles and goal-setting involving patient collaboration in order to improve the patients' knowledge and self-awareness .