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Apoptosis of vasopressinergic hypothalamic neurons in chronic diabetes mellitus. – PubMed


Retrospective analysis included clinical data from 241 patients admitted to the Department of Metabolic Diseases CMUJ in Krakow, 159 women (age 29.76 +/- 9.7, diabetes duration 10.00 +/- 8.6) and 82 men (age 36.52 +/- 13.4, diabetes duration 11.78 +/- 11.08). To evaluate whether diabetes can influence fibrosis and thus aggravate the pathological process, the progression of chronic pancreatitis was assessed in diabetic and non diabetic mice. Stroke risk was increased 2-fold in ESA-treated patients compared with patients in the placebo group in whom a median Hb level of 10.5g/dl was achieved. For the present analysis, ‘baseline’ was fixed at the ELSA wave 2 (2004/5) when biological data were first collected. In this time the renal Na(+),K(+)-ATPase undergoes structural changes in the vicinity of Na(+)-binding site resulting in worsened affinity to sodium in both genders as indicated by 13% and 18% increase of K(Na) value in female and male rats, respectively. However, corneal thickness, anterior radius and asphericity, and overall corneal power did not differ significantly between the groups. These results indicate that the time of examination after induction of diabetes critically influences glomerular Na+-K+-ATPase activity and suggest that sorbinil, at least in normal glomerular tissue, has a membrane-associated effect that may be independent of its aldose reductase-inhibiting property.

These data provide experimental and clinical evidence for a distinct post-MI autoimmune syndrome in T1D. (CPR 3.2) Diabetes and CKD are increasing among children and adolescents, however, stage 3 CKD or greater due to DKD remains rare in these groups.Children and adolescents are more likely than adults to revert from microalbuminuria to normoalbuminuria.Specialists in diabetes and kidney disease with experience in these age groups should be involved in their care.Treatment goals for glycemia in type 1 diabetes and CKD should follow the American Diabetes Association’s (ADA) Standards of Care for children and adolescents.

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