Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery. It is a naturally occurring thiol antioxidant, or simply stated, a sulfur containing chemical produced in plants and animals.1,2 It has been shown to have a remarkable ability to regenerate other major anti-oxidants and protect the body from oxidative stress. To show a positive influence of alpha lipoic acid on clinically manifested diabetic neuropathy symptoms as well as the effect of alpha lipoic acid in patients glycaemic control. The damaged nerves can cause misfiring messages which transfer pain signals to the brain despite there being no physical reason for pain. The participant will be assigned the cross over for 8 weeks on the opposite therapy. They reveal complex interrelationships among nerve perfusion, energy metabolism, osmolyte content, conduction velocity, and oxidative stress that may reflect the heterogeneous and compartmentalized composition of peripheral nerve. The first group (n=3) responded to R-ALA with a >25% drop in HbA1c range from 6.1-12.5 to 6.2- 9.0 mg/dL and/or halved their anti-diabetic medication.
Treatment of diabetic rats with low doses (20 mg kg(-1) day(-1)) of racLPA and GLA, while having modest effects on their own, showed evidence of marked synergistic action in joint treatment, completely correcting motor NCV and blood flow deficits. ALA is also being researched for its potential to treat HIV disease and multiple sclerosis. When it comes to the treatment of painful neuropathy, many of the current medications — such as gabapentin (Neurontin, Pfizer), pregabalin (Lyrica, Pfizer), serotonin–norepinephrine reuptake inhibitors, tricyclic antidepressants or analgesics — provide pain relief but do not affect the actual disease process. ALA is naturally synthesized in your body, therefore, no daily recommended doses have been established; however, the University of Maryland Medical Center states that ALA supplementation for general anti-oxidant support should typically range from 20 to 50 mg per day in adults. PLA). Do not use this product without medical advice if you are breast-feeding a baby. Surely if this method of treatment was adopted in the UK it would save the NHS a fortune?
Standardised mean differences were calculated using the Mantel-Haenszel method. Well, this is probably over-simplified but essentially it’s the result of our cells dying from oxidative stress and what helps fight this? Compared to common pain medications, ALA has fewer side effects, works faster, and may improve pain and muscle strength. Other general facts about alpha lipoic acid are that it is made and present in our bodies but it is bound to proteins and thus generally unusable at least at a therapeutic level. It is thought that alpha-lipoic acid can protect free radical damage caused by high blood glucose levels, thus counteracting nerve damage. Magnesium (250mg, powder) – Key mineral that can get washed out from acidic foods (meats, soda. After 12 months, researchers found that mental decline had stopped.
It is both water and fat-soluble meaning it can be used by our bodies all throughout. It’s an anti-inflammatory that can help treat or prevent cardiovascular diseases. Alpha-lipoic acid. ALA is not considered an essential nutrient meaning there is no RDA or recommended daily allowance. It is widely noted that side effects are very uncommon. However, if you currently take diabetes medication, the potential exists for hypoglycemia or low blood sugar. Cancer ChemotherPharmacol.
No woman should take ALA if she is pregnant or breast feeding and because ALA is seen as a powerful part of bodily function, taking the alpha lipoic acid supplements without one’s physician knowing about the regimen is not a good idea. Alpha-lipoic acid can decrease the level of sugar in blood. It also helps eliminate protein synthesis by-products and exercise induced stress. In fact, I stack (combine) alpha lipoic acid with CoQ10, B-complex, C, garcinia cambogia and an amino acid energy drink before I work out and I definitely feel more energetic and focused in the gym. I feel like I can keep going for a long time. A recent study of great significance published by the Germans reported that alpha-lipoic acid enhanced glucose disposal in patients with Type II diabetes (NIDDM). That said, an established safe range is 600-1200 mg /day.
It is highly recommended to take it on an empty stomach to enhance its bioavailability. I have noticed lately, that at times I get heartburn when I take ALA. So drink plenty of water. Also, don’t take it when you’re about lie down if it gives you heartburn. I’ll look into this and provide an update at a later date. ALA is one of the main supplements in my reverse type 2 diabetes arsenal and has been for many years. I personally target taking 600-800 mg /day and can’t see myself without it.