[ Diabetes Type 2 ]

6D.05: ENDOTHELIAL DYSFUNCTION IN ANIMAL MODELS OF GLUCOSE INTOLERANCE AND DIABETES IS ACCOMPANIED BY DIFFERENT


The aim of this study was to investigate the phenotypic parameters and associated factors characterizing the development of glucose intolerance in polycystic ovary syndrome (PCOS). In this prospective cohort study, 487 women underwent 1) antepartum GDM screening by a glucose challenge test (GCT) and a diagnostic oral glucose tolerance test (OGTT) and 2) postpartum metabolic characterization by OGTT at 3 months after delivery. Nonetheless, mechanistic studies suggest that OSA could contribute to impaired glucose metabolism via the effects of sleep fragmentation, sympathetic excitation and intermittent hypoxia (IH) on pancreatic B-cell function, insulin sensitivity, and systemic inflammation. At parturition, the mothers’ ages ranged from 14 to 43 years. Body mass index, waist and hip circumferences, fasting lipid profile and blood pressure were obtained. Mean of GGT was 25.3 ± 12.1 IU/L. However, evidence from recent research suggests that none of these factors plays a significant role in this regard.

Each woman underwent a two-step screening for GDM: universal early testing in women with high-risk characteristics and a standard 1-h 50-g oral glucose challenge test between 24 and 27 weeks’ gestation for those not previously found to have glucose intolerance. We evaluated endothelial function in isolated aortas by acetylcholine and sodium nitroprusside and used RT-qPCR to analyze the expression of enzymes producing EETs (Cyp2j4, Cyp2c23), HETEs (Cyp4a2 and Cyp4a3) and soluble epoxide hydrolase (Ephx2) degrading EETs.

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